Nadia Roan, PhD

Professor

The Roan Lab studies how intracellular and extracellular factors in the tissue microenvironment can affect infection by HIV, mucosal immunity, and reproductive health. We have demonstrated that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells through at least two distinct mechanisms: promoting viral entry, and altering the cellular state of T cells to render them more permissive to viral replication. To characterize the molecular basis of how intrinsic and extrinsic perturbations can render some subsets of CD4+ T cells more susceptible than others to HIV infection, we are using a variety of global gene expression analysis approaches, including CyTOF and RNA-seq. These approaches are also being used to characterize the HIV latent reservoir and the nature of viral rebound upon antiretroviral treatment interruption. Another research interest in the lab is to understand how factors in seminal plasma affect reproductive health and susceptibility to sexually transmitted diseases.

  • 05/2021 - Diversity, Equity, and Inclusion Champion Training, University of California

  • P50HD112034. PI of Project 1: Roan, NIH, 2023-2028

  • P01AI69606. PI of P01: Yukl, PI of Project 3: Roan, NIH, 2022-2027

  • P01AI69606. PI: Smith, NIH, 2022-2027

  • R01DK131526. PI: Roan, NIH, 2022-2027

  • R21AI170166. PI: Roan, NIH, 2022-2024

  • R21AI172060. PI: Roan, NIH, 2022-2024

  • CARE Collaboratory. PI: Margolis, NIH, 2021-2026

  • HOPE Collaboratory. PI: Ott, NIH, 2021-2026

  • R01AI147777 Supplement, NIH, 2021-2022

  • PBBR COVID-19 Grant. PI: Roan, Program for Breakthrough Biomedical Research, 2020-2021

  • Fast Grants for COVID-19 Research. PI: Roan, Fast Grants, 2020

  • R01AI147777. PI: Roan, NIH, 2019-2023

  • R01AI141003. PI: Henrich, NIH, 2018-2023

  • P01AI131374. PI of Project 1: Roan, NIH, 2017-2022

  • R15GM123447. PI: Jensen-Seaman, NIH, 2017-2020

  • R01AI127219. PI: Roan, NIH, 2016-2021

  • amfAR Cure Institute, amfAR, 2016-2021

  • R21AI122821. PI: Roan, NIH, 2016-2018

  • WIHS W16036 PI: Yukl, NIH, 2016-2017

  • NCTRI P50 Pilot Grant Award. PI: Roan, UCSF, NIH, 2016-2017

  • R21AI116252. PI: Roan, NIH, 2015-2017

  • Center for AIDS Research Basic Science HIV/AIDS grant, CFAR, 2014-2015

  • K99/R00 (K99AI103262, R00AI104262). PI: Roan, NIH, 2013-2016

  • Hellman Award for Early-Career Faculty, UCSF, 2013-2015

  • R01HD074511. PI: Pilcher, NIH, 2012-2017

  • KURe K12, NIH, 2012-2013

  • Centers for AIDS Research Early Career Award of Excellence in Basic Research, CFAR, 2012

  • Gladstone Institute of Virology and Immunology Award for Scientific Excellence, The J. David Gladstones Institutes, 2012

  • A.P. Giannini Foundation Postdoctoral Fellowship, A.P. Giannini Foundation, 2008-2010

  • Travel Award for the 11th International Symposium on Human Chlamydial Infections, NIH, 2006

  • Manfred Karnovsky Fellowship Award, Harvard Medical School, 2004

  • National Science Foundation Pre-Doctoral Fellowship, NSF, 2001-2004

  • F.H. Carpenter Memorial Price in Biochemistry, U.C. Berkeley, 2001

  • Outstanding Scholar Award, U.C. Berkeley, 2001

  • University Medal Finalist, U.C. Berkeley, 2001

  • March 1, 2024 - February 28, 2029 - Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIV , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI183286
  • August 1, 2023 - April 30, 2028 - Immunological, epigenetic and developmental determinants of early pregnancy success , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50HD112034
  • July 1, 2022 - June 30, 2027 - Multiomics characterization, induction, and elimination of the HIV gut reservoir , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK131526
  • May 1, 2022 - April 30, 2027 - The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI169606
  • May 1, 2022 - April 30, 2027 - Reservoir features associated with time-to-rebound during analytical treatment interruption , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01AI69606
  • April 1, 2022 - March 31, 2027 - Leaving, Coming, and Staying HIV Obligate Microenvironments (HOME) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI169609
  • July 1, 2024 - May 31, 2026 - Serological and cellular immune response to SARS-CoV-2 vaccination in pediatric multiple sclerosis on immunotherapy , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R21AI180928
  • August 16, 2021 - April 30, 2026 - Collaboratory of AIDS Researchers for Eradication (CARE) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UM1AI164567
  • August 16, 2021 - April 30, 2026 - HOPE - HIV Obstruction by Programmed Epigenetics , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UM1AI164559
  • April 1, 2019 - March 31, 2026 - SF Bay Area MACS/WIHS Combined Cohort Study , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U01HL146242
  • July 1, 2022 - June 30, 2024 - Characterizing ART-free NK cell-mediated control of HIV infection in people living with HIV , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI172060
  • August 1, 2019 - July 31, 2023 - Phenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologies , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI147777
  • May 15, 2018 - April 30, 2023 - Targeting Non Viral Markers of HIV Persistence , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI141003
  • August 8, 2017 - July 31, 2022 - Exploiting the Host-HIV Interface To Identify Biomarkers Predicting Time to Viral Rebound after Treatment Interruption , Principal Investigator of Project 1 . Sponsor: NIH, Sponsor Award ID: P01AI131374
  • July 1, 2022 - June 30, 2022 - Single-cell analysis of glycomic and proteomic features of the HIV reservoir , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI170166
  • September 26, 2016 - August 31, 2021 - Elucidating the mechanism of progesterone-induced permissivity in the upper female reproductive tract , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI127219
  • July 1, 2015 - June 30, 2019 - Characterization of Gallic Acid as a Novel HIV Microbicide Candidate , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI116252
  • March 1, 2016 - February 28, 2019 - Characterization of Exosomes From Semen of Uninfected and HIV-Infected Men , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI122821
  • May 15, 2013 - November 30, 2016 - Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00AI104262
  • May 15, 2013 - April 30, 2014 - Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99AI104262

Nadia Roan, PhD