Tippi Mackenzie, MD

Professor

Tippi MacKenzie is a pediatric and fetal surgeon who is focused on developing better ways to diagnose and treat genetic diseases before birth. She leads a translational research lab examining the unique biology between the mother and her fetus, with the idea that pregnancy complications such as preterm labor arise from a breakdown in maternal-fetal tolerance. At present, the MacKenzie group is focused on preterm labor and fetal therapies including stem cell transplantation, enzyme replacement therapy, and gene therapy.

  • Fellow, 2007 - Pediatric Surgery, Children's Hospital of Philadelphia
  • Chief Resident, 2005 - Surgery, Brigham and Women's Hospital
  • Residency, 2004 - Surgery, Brigham and Women's Hospital
  • Postdoctoral Studies, 2002 - Fetal Therapy, Children's Hospital of Philadelphia
  • M.D., 1997 - Medicine, Stanford University

  • September 20, 2022 - April 30, 2027 - Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases , Principal Investigator . Sponsor: NIH/NICHHD, Sponsor Award ID: 1R01HD110270
  • January 1, 2022 - December 31, 2025 - Developing gene therapy strategies to treat alpha thalassemia , Principal Investigator . Sponsor: NIH/NHLBI, Sponsor Award ID: 1R01HL161291-01
  • August 21, 2019 - July 31, 2024 - Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI145858
  • August 1, 2017 - July 31, 2022 - In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial) , Principal Investigator . Sponsor: California Institute for Regenerative Medicine (CIRM), Sponsor Award ID: CLIN2-09183
  • July 1, 2017 - June 30, 2021 - A precision medicine approach to detect dysbiosis and immune activation in preterm labor , Principal Investigator . Sponsor: Burroughs Wellcome Fund Preterm Labor Initiative, Sponsor Award ID:
  • June 15, 2015 - May 31, 2021 - T cell activation and the breakdown of maternal-fetal tolerance in preterm labor , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI116880

Tippi MacKenzie, MD