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UCSF

ObGyn&RS

Center for Reproductive Sciences

Research Programs

CRS research spans reproductive endocrinology, developmental and implantation biology, reproductive oncology, and fetal origins of adult disease. Although mammalian models are primarily and widely adopted for these research programs, model organisms such as yeast, Drosophila, zebra fish, and frog models of reproduction are also used to elucidate specific aspects of gamete development and function. State of the art technologies in cell and molecular biology, nucleic acid and protein biochemistry are currently in use in CRS laboratories. A large number of engineered mouse models, as well as cultured cells, including human stem cells, are also available and exchanged among the CRS members.

A Summary of Programs and Principal Investigators

Reproductive Endocrinology

  1. Synthesis and mechanisms of action of steroid hormones (Walter Miller, Sindy Mellon, Holly Ingraham, and Nirao Shah)
  2. Mechanism of action of gonadotropic hormones (Marco Conti)
  3. Genetics of steroidogenesis

Reproductive Developmental Biology

  1. Early embryo development (Susan Fisher, Robert Blelloch, Miguel Ramalho-Santos, Paolo Rinaudo, Marco Conti)
  2. Regulation of pluripotency (Robert Blelloch, Miguel Ramalho-Santos)
  3. Primordial germ cell specification and migration (Diana Laird)
  4. Regulation of meiotic chromosome recombination (Jennifer Fung)
  5. The gonadal "niche" and its role in pluripotency (Todd Nystul)
  6. Mechanisms of oocyte maturation, ovulation, and early embryo development (Marco Conti)

Implantation Biology

  1. Genetic programs underlying uterine receptivity (Linda Giudice)
  2. Trophoblast development and function (Susan Fisher)
  3. Effect of embryo culture on placentation (Paolo Rinaudo)

Reproductive Oncology

  1. Mechanisms of cell resistance to chemotherapy
  2. Stem cells and ovarian cancer
  3. Cervical cancer (Karen Smith-McCune)

UCSF NIH National Center for Translational Research in Reproduction and Infertility (NCTRI)