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UCSF

Department of

Obstetrics, Gynecology & Reproductive Sciences

Zika resources for patients and providers

Zika Virus Resources and Information for Healthcare Providers

Latest Publications

Original Article:
Persistence of Zika Virus in Body Fluids — Preliminary Report

Gabriela Paz-Bailey, M.D., Ph.D., Eli S. Rosenberg, Ph.D., Kate Doyle, M.P.H., Jorge Munoz-Jordan, Ph.D., Gilberto A. Santiago, Ph.D., Liore Klein, M.S.P.H., Janice Perez-Padilla, M.P.H., Freddy A. Medina, Ph.D., Stephen H. Waterman, M.D., M.P.H., Carlos Garcia Gubern, M.D., Luisa I. Alvarado, M.D., and Tyler M. Sharp, Ph.D.
February 14, 2017 DOI: 10.1056/NEJMoa1613108

Correspondence from The New England Journal of Medicine:
Zika Virus and the Guillain–Barré Syndrome — Case Series from Seven Countries
August 31, 2016 DOI: 10.1056/NEJMc1609015
Correspondence from The New England Journal of Medicine
Prolonged Shedding of Zika Virus Associated with Congenital Infection: PDF iconnejmc1607583.pdf
Correspondence from The New England Journal of Medicine
Miscarriage Associated with Zika Virus Infection

July 27, 2016 DOI: 10.1056/NEJMc1605898

CDC assisting Utah investigation of Zika virus infection apparently not linked to travel Full Story Here
Monday, July 18, 2016
Summary: CDC is assisting in the investigation of a case of Zika in a Utah resident who is a family contact of the elderly Utah resident who died in late June. The deceased patient had traveled to an area with Zika and lab tests showed he had uniquely high amounts of virus—more than 100,000 times higher than seen in other samples of infected people—in his blood. Laboratories in Utah and at the Centers for Disease Control and Prevention (CDC) reported evidence of Zika infection in both Utah residents.

Latest news from the CDC Morbidity and Mortality Weekly Report (MMWR)

Suspected Female-to-Male Sexual Transmission of Zika Virus – New York City, 2016 – Full Story Here

Early Release / July 15, 2016 / 65
Davidson A, Slavinski S, Komoto K, Rakeman J, Weiss D. Suspected Female-to-Male Sexual Transmission of Zika Virus — New York City, 2016. MMWR Morb Mortal Wkly Rep. ePub: 15 July 2016. DOI: http://dx.doi.org/10.15585/mmwr.mm6528e2.

Summary: The New York City Department of Health and Mental Hygiene recently reported a suspected female-to-male sexual transmission of Zika virus. A woman engaged in sex without a condom with a male partner the day she returned to NYC from travel to an area with ongoing Zika virus transmission. Her serum and urine later tested positive for Zika virus RNA. Seven days after intercourse with the woman, the male partner developed Zika-related symptoms. Zika virus RNA was detected in his urine but not serum. An extensive interview revealed the man had not traveled outside the United States during the year before his illness, had any other recent sexual partners, or been bitten by a mosquito.

The Lancet: Infectious Diseases

Zika virus in the female genital tract:

Nadia Prisant, Louis Bujan, Hélène Benichou, Pierre-Humbert Hayot, Lynda Pavili, Sylvia Lurel, Cecile Herrmann, Eustase Janky, Guillaume Joguet
Published Online: 11 July 2016

Summary: The first human Zika virus infection was documented in Nigeria in 1954, with very few documented infections after this initial report, until the virus outbreak in 2007 on Yap Island in the western Pacific Ocean. The infection is usually asymptomatic but symptoms can consist of fever, maculopapular rash, arthralgia, and conjunctivitis.

CDC Control and Prevention: Emerging Infectious Diseases,

Volume 22, Number 7—July 2016

A Literature Review of Zika Virus

Author affiliations: University of California, San Francisco, California, USA (A.R. Plourde); The Johns Hopkins University, Baltimore, Maryland, USA (E.M. Bloch); Blood Systems Research Institute, San Francisco (E.M. Bloch)
Abstract: Zika virus is a mosquitoborne flavivirus that is the focus of an ongoing pandemic and public health emergency. Previously limited to sporadic cases in Africa and Asia, the emergence of Zika virus in Brazil in 2015 heralded rapid spread throughout the Americas. Although most Zika virus infections are characterized by subclinical or mild influenza-like illness, severe manifestations have been described, including Guillain-Barre syndrome in adults and microcephaly in babies born to infected mothers. Neither an effective treatment nor a vaccine is available for Zika virus; therefore, the public health response primarily focuses on preventing infection, particularly in pregnant women. Despite growing knowledge about this virus, questions remain regarding the virus’s vectors and reservoirs, pathogenesis, genetic diversity, and potential synergistic effects of co-infection with other circulating viruses. These questions highlight the need for research to optimize surveillance, patient management, and public health intervention in the current Zika virus epidemic.

Link to PDF here: PDF iconPlourde, Bloch_Lit Review Zika_072106.pdf

Figure 1, Literature Review Zika Virus, 062016 CDC