Nadia Roan, PhD

Professor

The Roan Lab studies how intracellular and extracellular factors in the tissue microenvironment can affect infection by HIV, mucosal immunity, and reproductive health. Her lab has developed, implemented, and adapted a variety of single-cell “omics” tools to identify and characterize rare populations of HIV reservoir cells in order to better understand mechanisms of HIV replication and persistence. These technologies include the development of a variety of CyTOF panels to characterize the protein, glycan, and viral sensing features of HIV-infected cells, computational approaches to trace reactivated HIV reservoir cells to their pre-stimulated states, and multi-omics single-cell sequencing approaches to define the transcriptome, surface proteome, and clonal expansion histories of active HIV reservoir cells from blood and tissues of people with HIV. Her lab is also using “omics” tools to characterize HIV-specific effector immune responses, including in natural controllers of HIV. Finally, her lab also studies the mechanisms driving Long COVID and other inflammatory conditions that disproportionately affect women, and the role of various lymphocyte subsets in female fertility and women's health.

  • 05/2021 - Diversity, Equity, and Inclusion Champion Training, University of California

  • P50HD112034. PI of Project 1: Roan, NIH, 2023-2028

  • P01AI69606. PI of P01: Yukl, PI of Project 3: Roan, NIH, 2022-2027

  • P01AI69606. PI: Smith, NIH, 2022-2027

  • R01DK131526. PI: Roan, NIH, 2022-2027

  • R21AI170166. PI: Roan, NIH, 2022-2024

  • R21AI172060. PI: Roan, NIH, 2022-2024

  • CARE Collaboratory. PI: Margolis, NIH, 2021-2026

  • HOPE Collaboratory. PI: Ott, NIH, 2021-2026

  • R01AI147777 Supplement, NIH, 2021-2022

  • PBBR COVID-19 Grant. PI: Roan, Program for Breakthrough Biomedical Research, 2020-2021

  • Fast Grants for COVID-19 Research. PI: Roan, Fast Grants, 2020

  • R01AI147777. PI: Roan, NIH, 2019-2023

  • R01AI141003. PI: Henrich, NIH, 2018-2023

  • P01AI131374. PI of Project 1: Roan, NIH, 2017-2022

  • R15GM123447. PI: Jensen-Seaman, NIH, 2017-2020

  • R01AI127219. PI: Roan, NIH, 2016-2021

  • amfAR Cure Institute, amfAR, 2016-2021

  • R21AI122821. PI: Roan, NIH, 2016-2018

  • WIHS W16036 PI: Yukl, NIH, 2016-2017

  • NCTRI P50 Pilot Grant Award. PI: Roan, UCSF, NIH, 2016-2017

  • R21AI116252. PI: Roan, NIH, 2015-2017

  • Center for AIDS Research Basic Science HIV/AIDS grant, CFAR, 2014-2015

  • K99/R00 (K99AI103262, R00AI104262). PI: Roan, NIH, 2013-2016

  • Hellman Award for Early-Career Faculty, UCSF, 2013-2015

  • R01HD074511. PI: Pilcher, NIH, 2012-2017

  • KURe K12, NIH, 2012-2013

  • Centers for AIDS Research Early Career Award of Excellence in Basic Research, CFAR, 2012

  • Gladstone Institute of Virology and Immunology Award for Scientific Excellence, The J. David Gladstones Institutes, 2012

  • A.P. Giannini Foundation Postdoctoral Fellowship, A.P. Giannini Foundation, 2008-2010

  • Travel Award for the 11th International Symposium on Human Chlamydial Infections, NIH, 2006

  • Manfred Karnovsky Fellowship Award, Harvard Medical School, 2004

  • National Science Foundation Pre-Doctoral Fellowship, NSF, 2001-2004

  • F.H. Carpenter Memorial Price in Biochemistry, U.C. Berkeley, 2001

  • Outstanding Scholar Award, U.C. Berkeley, 2001

  • University Medal Finalist, U.C. Berkeley, 2001

  • March 1, 2024 - February 28, 2029 - Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIV , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI183286
  • August 1, 2023 - April 30, 2028 - Immunological, epigenetic and developmental determinants of early pregnancy success , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50HD112034
  • July 1, 2022 - June 30, 2027 - Multiomics characterization, induction, and elimination of the HIV gut reservoir , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK131526
  • May 1, 2022 - April 30, 2027 - The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI169606
  • May 1, 2022 - April 30, 2027 - Reservoir features associated with time-to-rebound during analytical treatment interruption , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01AI69606
  • April 1, 2022 - March 31, 2027 - Leaving, Coming, and Staying HIV Obligate Microenvironments (HOME) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI169609
  • July 1, 2024 - May 31, 2026 - Serological and cellular immune response to SARS-CoV-2 vaccination in pediatric multiple sclerosis on immunotherapy , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R21AI180928
  • August 16, 2021 - April 30, 2026 - Collaboratory of AIDS Researchers for Eradication (CARE) , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UM1AI164567
  • August 16, 2021 - April 30, 2026 - HOPE - HIV Obstruction by Programmed Epigenetics , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UM1AI164559
  • April 1, 2019 - March 31, 2026 - SF Bay Area MACS/WIHS Combined Cohort Study , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U01HL146242
  • July 1, 2022 - June 30, 2024 - Characterizing ART-free NK cell-mediated control of HIV infection in people living with HIV , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI172060
  • August 1, 2019 - July 31, 2023 - Phenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologies , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI147777
  • May 15, 2018 - April 30, 2023 - Targeting Non Viral Markers of HIV Persistence , Co-Investigator . Sponsor: NIH, Sponsor Award ID: R01AI141003
  • August 8, 2017 - July 31, 2022 - Exploiting the Host-HIV Interface To Identify Biomarkers Predicting Time to Viral Rebound after Treatment Interruption , Principal Investigator of Project 1 . Sponsor: NIH, Sponsor Award ID: P01AI131374
  • July 1, 2022 - June 30, 2022 - Single-cell analysis of glycomic and proteomic features of the HIV reservoir , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI170166
  • September 26, 2016 - August 31, 2021 - Elucidating the mechanism of progesterone-induced permissivity in the upper female reproductive tract , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI127219
  • July 1, 2015 - June 30, 2019 - Characterization of Gallic Acid as a Novel HIV Microbicide Candidate , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI116252
  • March 1, 2016 - February 28, 2019 - Characterization of Exosomes From Semen of Uninfected and HIV-Infected Men , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI122821
  • May 15, 2013 - November 30, 2016 - Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00AI104262
  • May 15, 2013 - April 30, 2014 - Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99AI104262

Nadia Roan, PhD