Nadia Roan, PhD

The Roan Lab studies how intracellular and extracellular factors in the tissue microenvironment can affect infection by HIV, mucosal immunity, and reproductive health. Her lab has developed, implemented, and adapted a variety of single-cell “omics” tools to identify and characterize rare populations of HIV reservoir cells in order to better understand mechanisms of HIV replication and persistence. These technologies include the development of a variety of CyTOF panels to characterize the protein, glycan, and viral sensing features of HIV-infected cells, computational approaches to trace reactivated HIV reservoir cells to their pre-stimulated states, and multi-omics single-cell sequencing approaches to define the transcriptome, surface proteome, and clonal expansion histories of active HIV reservoir cells from blood and tissues of people with HIV. Her lab is also using “omics” tools to characterize HIV-specific effector immune responses, including in natural controllers of HIV. Finally, her lab also studies the mechanisms driving Long COVID and other inflammatory conditions that disproportionately affect women, and the role of various lymphocyte subsets in female fertility and women's health.