Gynecologic Oncology Division

The Division of Gynecologic Oncology provides a comprehensive approach for our patients, researchers and students. Our division focuses on research and treatment of cancers of the reproductive tract. Our clinicians are board certified gynecologic oncologists and experts in the prevention and management of precancerous abnormalities, such as dysplasia and hyperplasia, and cancer involving the vulva, vagina and cervix, uterus, fallopian tube and ovary. 

The Division provides clinical training for fellows, residents and medical students through its multidisciplinary practices at the UCSF Ron Conway Gateway Medical Building and surgical and inpatient care of women at UCSF Bakar Cancer Hospital at the new Mission Bay Campus. Faculty are engaged in research investigating the pathogenesis, detection and treatment of cervical, ovarian and endometrial cancer.

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Lee-may Chen

Division Director: Lee-may Chen, MD, FACS, FACOG

As a clinical and academic division, our priorities are:

  • Patient Care: To provide early cancer diagnosis, state-of-the-art treatment and compassionate care
  • Research: To discover, develop, and deliver advancements in early detection, treatment and prevention of cancers of the reproductive tract
  • Education: To train and inspire future leaders in gynecologic oncology and partner with community and national organizations in promoting cancer awareness and treatment via scholarship and policy

Division Highlights

Gynecologic Oncology Practice
Our Gynecologic Oncologists are committed to meeting the complex needs of women with cancers of the reproductive tract. Our unique multidisciplinary team of physicians and health care staff gynecologic specialists, radiation oncologists, medical oncologists and nurses all have specialized training in caring for patients with gynecologic cancers. Using a team approach, we are able to advise women and their families of the latest treatment options and offer timely, innovative and compassionate care in a personal and supportive environment.

Gynecologic Dysplasia Clinic
Established over 50 years ago, the UCSF/Mount Zion Dysplasia Clinic is a specialty clinic focused on the care of individuals with diseases of the cervix, vulva and vagina associated with human papillomavirus (HPV). These diseases include dysplastic (precancerous) lesions.

UCSF Hereditary Cancer Clinic
The Gynecologic Oncology Program works closely with the UCSF Hereditary Cancer Clinic to offer patients and families with genetic mutations linked to hereditary cancers – such as mutations of BRCA1 or BRCA2 – personalized care and planning for their long-term health. Our counseling encompass symptom review, chemoprevention, early detection, and risk-reducing surgery. We also coordinate surveillance and follow-up care, with referrals to other specialty clinics at UCSF as needed. The clinic is part of the UCSF Center for BRCA Research. Our team of clinicians and investigators is dedicated to developing new treatments, improving patient outcomes and survival rates, and providing more personalized care to families who carry mutations linked to hereditary cancers.

Gynecologic Cancer Tissue Bank
Our gynecologic oncology tissue bank was established in 1996 and is a clinically annotated resource of tissue and matched blood to support research investigations nationwide. We have contributed high-quality specimens to research projects such as The Cancer Genome Atlas (TCGA) and other NCI designated cancer centers. It is the mission of the tissue bank to support both internal and external research investigations to improve our understanding of the biology of gynecologic cancer in service to the identification of novel cancer treatments. We currently have more than 1,500 annotated human cancer specimens from the full spectrum of rare and common gynecologic cancers. The Gynecologic Oncology tissue bank is supported by private and departmental funding. We are interested in exploring collaborations.

Please contact [email protected] if interested.

Global Health Medical Training and Research in Uganda 

Unfortunately, there is great disparity in access to cancer treatment and outcomes around the world. While low and middle-income countries (LMICs) experience the greatest burden in terms of incidence, morbidity and mortality of cancer, just a fraction (7% ) of total resources spent on cancer worldwide are dedicated to these less-developed countries. This funding discrepancy leads to limited options and poor outcomes.

UCSF’s division of gynecologic oncology is working to improve gynecologic cancer care in sub-Saharan Africa though education, clinical capacity building, and research. We have developed a bilateral exchange and partnership with the Uganda Cancer Institute and Mulago University, which serves as the largest public institutions for women's and cancer care in Uganda.

Worldwide, cervical cancer is the fourth most common cancer among women, but in Uganda, like many countries in East Africa, cervical cancer is the most common malignancy and is responsible for the greatest cancer-related mortality among women. Because of a lack of systematic screening and early detection, most women present with advanced-stage disease and survival is poor. Dr. Megan Swanson's research is focused on the disparities in access to care and in outcomes for women with cervical cancer as well as in the availability of effective screening and prevention methods. She has worked on identifying barriers and facilitators to cervical cancer screening and care in East Africa and is developing innovative pilot implementation projects in Uganda to increase screening and treatment opportunities.

Since 2011, Dr. Stefanie Ueda has been training physicians from Africa in complex surgery and cancer directed care. Through philanthropic efforts, the first in-country fellowship in Uganda was started in October 2017. Nine graduates have successfully completed the program as of January 2023, including physicians from Tanzania and Liberia. Our fellowship program has been selected by the Society of Gynecologic Oncologists and the International Gynecologic Cancer Society as an international training site in gynecologic cancer care and education, with one of the largest number of graduates among programs worldwide.

We thank Dr. John Kerner, Dr. Edward Hill, and their families for their generous support. If you would like to donate to these projects, please feel free to contact our office.

Winning the War on Women's Cancer - Introduction to Women's Cancers UCSF Osher Center for Integrative Medicine Mini Medical School for the Public​

As gynecologic cancers can be devastating diseases, they can affect nearly everyone directly or indirectly in our society. In recent discoveries and advance treatments Dr. Chen and the Division of Gynecologic Cancer were able to understand the biology and genetics of these cancers. This helped provide new strategies for prevention, early detection of these cancers, and new types of cancer therapy that target gynecologic cancers more specifically with fewer side effects. As a result, death rates have decreased and the improvement of quality life increased. By viewing these course lectures you will learn how early detection, improvement of side effects from novel treatments assist improve the cure and quality of life for those with gynecologic cancers.

The Division of Gynecologic Oncology has one of the largest Clinical Trial Research Programs in Northern California and is on the forefront of translational research in gynecologic cancers. Through the collaborative work of our providers, research team and other UCSF staff, we offer a wide variety of clinical trials that provide women with gynecologic cancers access to cutting edge investigational therapies and treatment methods. Our practice serves as a regional research hub which attracts patients from across California seeking out clinical trials. Additionally, we are a voting member of the national Cooperative Group NRG Oncology, an interdisciplinary research organization dedicated to improving the survival and quality of life of cancer patients through research, where we help to shape Gynecologic Oncology care on a national and global level. We are excited to continue to grow our Clinical Research Program by adding additional staff and expanding our trial portfolio, with the goal of being able to provide any woman with gynecologic cancer interested in participating in a clinical trial access to potentially life-saving therapy.

The following trials are currently open to accrual:

Cooperative Group Trials

  • NRG-CC008: A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk]
    • Now open to accrual
    • NCT04251052
       
  • NRG-GY027: Phase I/IB Safety and Pharmacodynamic Study of Neoadjuvant (NACT) Paclitaxel and Carboplatin with Ipatasertib as Initial Therapy of Ovarian Cancer PTMA 100805
    • Now open to accrual
    • NCT05276973

Industry Trials

  • UAB 2031: Single-Arm Phase II Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy With Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer Who Are Folate Receptor α Positive
    • Now open to accrual
    • NCT04606914
       
  • AFT-50: A Phase IB/II Multi-Cohort Study of Targeted Agents and/or Immunotherapy With Atezolizumab for Patients With Recurrent or Persistent Endometrial Cancer [EndoMAP]
    • Now open to accrual
    • NCT04486352
       
  • GOG-3065 ZN-C3-004: A Phase 2 Open-Label, Multicenter Study to Evaluate Efficacy and Safety of ZN-c3 in Adult Women With Recurrent or Persistent Uterine Serous Carcinoma [TETON]
    • Now open to accrual
    • NCT04814108
       
  • GOG-3097: A Phase 3, Randomized, Open-Label Study of Combination Therapy With Avutometinib Plus Defactinib Versus Investigator's Choice of Treatment in Patients With Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) [RAMP 301]
    • Now open to accrual
    • NCT06072781

 

For more information:

[email protected]

UCSF Clinical Trials

 

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