Improving the Identification of Deep Infiltrating Endometriosis with Estrogen Receptor Targeted Positron-Emission Tomography/Magnetic Resonance Imaging (PET/MRI)
Courtney Lawhn Health, MD, Principal Investigator and
Jeannette Lager, MD, MPH, Co - Principal Investigator
Purpose
This is a pilot study to determine the feasibility of estrogen receptor (ER) targeted18F-flourestradiol (FES) PET/MRI in endometriosis. We will determine whether FES/MRI improves the detection of endometriosis lesions compared to MRI alone.
Eligibility Criteria
Inclusion:
1. Age 18 yrs or older
2. Suspicion of deep infiltrating endometriosis based on one or more of the following: prior imaging findings (MRI and/or ultrasound) OR suggestive clinical symptomatology as determined according to standard of care by the treating gynecologist
3. No hormone treatment for at least 2 consecutive menstrual cycles
4. No treatment with gonadotropic-releasing hormone analogs for at least 3 months
5. Ability to give written informed consent and willingness to comply with the requirements of the protocol
Exclusion:
1. Pregnancy
2. Hypersensitivity to gadolinium-based contrast agents
3. Severe claustrophobia limiting ability to undergo PET/MRI
4. Inability to lie flat for 60 minutes
5. Any condition that compromises compliance with the objectives and procedures of this protocol, as judged by the principal investigator
If you have an eligible patient or have any questions, please contact the study’s Clinical Research Coordinator Khadija Siddiqua:
[email protected]
415-476-4302